High fat diet and hyperinsulinemia

Cancer, Diabetes, Osteoporosis etc.
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dime
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Joined: Mon 14 Feb 2011 09:24

High fat diet and hyperinsulinemia

Post by dime »

I came across an interesting table while looking at this paper
"Effect of Short- and Long-Term High-Fat Feeding on Autophagy Flux and Lysosomal Activity in Rat Liver"

HF-2 and HF-10 are 2 and 10 week high fat diets, where fat was w.w. 33% (99% lard + 1% soybean oil), protein 14%, starch 17%, vs SD which was protein 22%, fat 3%, starch 68%.

The HF-10 rats developed hyperinsulinemia, but not SD/HF-2. I'm interested whether high fat diet has similar effect in humans.
Here's the observation of the authors:
We found no difference in body weight among
experimental groups (Table 3). The adiposity (expressed
as weight of epididymal fat pad per 100 grams body
weight) was similar in SD and HF-2 but significantly
higher in HF-10. Fasting glycaemia was elevated in both
HF-2 and HF-10 groups but hyperinsulinemia was proved
only in HF-10. The alterations in glucose metabolism
were not accompanied by fasting hypertriglyceridemia.
The increased fat utilisation for energy production was
documented by the elevation of β-hydroxybutyrate
content in serum in HF-2 and HF-10 animals.
Interestingly, ketogenesis in fasting is lower in HF-10
compared with HF-2 group (P=0.035) which suggests a
tendency to the attenuation of TAG utilisation in the
liver. As expected, compared with the SD group, the HF
diet administered animals accumulated an increased
amount of TAG in the liver depending on the length of
diet administration.
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dime
Posts: 1238
Joined: Mon 14 Feb 2011 09:24

Re: High fat diet and hyperinsulinemia

Post by dime »

Dietary Fat Can Affect Insulin Requirements in Type 1 Diabetes
Study results showed that participants required more insulin after eating the high-fat dinner than the low-fat dinner (12.6 units compared to 9 units). In contrast, the two breakfast meals required similar insulin doses. Despite the increased insulin, participants had greater hyperglycemia after the high-fat dinner with insulin levels elevated five to ten hours after the meal. The average increase in insulin was 42 percent with significant individual differences.
fred
Posts: 342
Joined: Sun 07 Feb 2010 14:57

Re: High fat diet and hyperinsulinemia

Post by fred »

Apparently cheese was the source of fat, and dairy is known to be insulinogenic :

http://care.diabetesjournals.org/conten ... l.pdf+html :

"All subjects had the same foods for the LF dinner (grilled chicken breast, rice, broccoli, carrots, green salad, and grapes)
and for the HF dinner (grilled cheese sandwich, green salad with added cheese, croutons, and grilled chicken, and orange slices)."
overkees
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Joined: Fri 05 Aug 2011 14:20

Re: High fat diet and hyperinsulinemia

Post by overkees »

I read some old reports of diabetics that have been treated with sugar and fructose and abstinence from fluids that were quite succesful. If you're interested I will try to find them again.
dime
Posts: 1238
Joined: Mon 14 Feb 2011 09:24

Re: High fat diet and hyperinsulinemia

Post by dime »

overkees wrote:It's very cool, I read some old reports of diabetics that have been treated with sugar and fructose and abstinence from fluids that were quite succesful. If you're interested I will try to find them again.
That sounds very strange, please post them in case you find them, I'm very curious.
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